The rapid mutation and spread of COVID variants has made it clear that containment, or ‘covid-zero’, is no longer sustainable, countries will have to adapt to living with the virus, and the road map back to normality, or our new normal, will be led by vaccines. In this respect, the “end” of the COVID-19 pandemic is likely to be similar to previous plagues like the Spanish Flu, which became the common flu virus. (The same novel strain of flu introduced in 1918 is the direct ancestor of every seasonal and pandemic flu over the past 100 years). The Spanish flu was thought to have ended a year later, in the spring of 1919, but flared up again in early 1920. By the middle of 1920 however, the deadly strain of flu had in fact faded enough that the pandemic was over in many places, even though there was no official declaration that the pandemic had ‘ended’. Unlike Covid-19, the world in 1920 did not have vaccines. The Spanish flu ended simply because the virus had infected enough people, and more importantly, enough people retained immunity that the virus was unable to find new susceptible hosts, in scientific terms, when R<1.0. An estimated third of the world’s population had caught the Spanish Flu by 1920; a WHO estimate in end-2020, prior to the emergence of the Delta variant in India and the winter wave in many countries, suggested that only 10% of the world’s population had caught the virus. Further, the risk of reinfections and fading antibodies in infected patients all suggest that COVID-19, in the near-term at least, will not be completely eradicated and governments will likely continue to exercise caution over their travel and reopening policies.